Here are some insights into the plans for the next TYPO3 release. Sounds quite much for the next regular release. I think the most needed feature is FAL (file abstraction layer). Rewriting the backend again for another JavaScript library? Do you really need a mobile version of your backend?
TYPO3 6.0 - Back to the Future on Typo3
Back on track, embracing the Future. Our ideas for the upcoming TYPO3 6.0 release.